Related Experiment Video

Updated: Sep 15, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
06:15

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation

Published on: November 10, 2023

1.0K

Postinfectious Bronchiolitis Obliterans in Children

Linfang Wan1, Zhonghong Wang1

  • 1Department of Pediatrics, First People's Hospital of Jingzhou, Jingzhou, Hubei, China.

Canadian Respiratory Journal
|July 15, 2025
PubMed

Insights

Pediatric postinfectious bronchiolitis obliterans, a lung disease, needs better early diagnosis. This review synthesizes expert consensus and research on diagnosis, treatment, and prevention for children.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Bronchiolitis obliterans is a rare obstructive lung disease, often post-infectious in children.
  • Adenovirus and Mycoplasma pneumoniae are key pathogens, impacting lung function post-illness.
  • Current diagnosis via lung biopsy hinders early detection and intervention.

Purpose of the Study:

  • To provide a comprehensive overview of early diagnosis, treatment, and prevention of pediatric postinfectious bronchiolitis obliterans.
  • To synthesize the 2023 China Expert Consensus and recent studies.
  • To identify future research directions for improved understanding and management.

Main Methods:

  • Literature review and synthesis of recent studies.
  • Analysis of the 2023 China Expert Consensus on Diagnosis and Treatment of Bronchiolitis Obliterans in Children.
  • Focus on early detection, treatment modalities, and preventive strategies.

Main Results:

  • Highlights the challenges in early diagnosis due to reliance on invasive methods.
  • Summarizes current expert recommendations for managing pediatric bronchiolitis obliterans.
  • Identifies gaps in knowledge and areas for future research.

Conclusions:

  • Early diagnosis and timely intervention are critical for pediatric postinfectious bronchiolitis obliterans.
  • Further research is needed to develop non-invasive diagnostic tools and refine treatment protocols.
  • Enhanced understanding will improve clinical management and outcomes for affected children.

Keywords:
Mycoplasma pneumoniae pneumoniaadenovirus pneumoniabronchiolitischildren

More Related Videos

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

20.6K
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

23.0K

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.1K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.8K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
531
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
319