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Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

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Metallic Nanoparticles Applications in Neurological Disorders: A Review.

Ernesto Ibarra-Ramírez1,2,3,4, Melissa Montes2, Roger Alexei Urrutia3

  • 1Faculty of Biosciences and Public Health, Specialized University of the Americas (UDELAS), Panama City, Panama.

International Journal of Biomaterials
|July 15, 2025
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Summary

Metallic nanoparticles offer unique properties for neurological disorder management, aiding in drug delivery and diagnostics. Despite promise, clinical use lags behind polymer nanoparticles, requiring further investigation into their application and effects.

Keywords:
biomedical engineeringgold nanoparticlesmagnetic nanoparticlesmetallic nanoparticlesneurological disorderssilver nanoparticlestissue regenerationtitanium nanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Neuroscience

Background:

  • Metallic nanoparticles (NPs) exhibit unique physicochemical properties suitable for neurological applications.
  • Their potential in drug delivery, diagnostics, and therapy for neurological disorders is significant.
  • Challenges remain in their widespread clinical implementation compared to polymer-based NPs.

Purpose of the Study:

  • To examine the physicochemical properties of metallic NPs for neurological applications.
  • To summarize their diagnostic and therapeutic roles in the central nervous system (CNS).
  • To discuss the incorporation and human body effects of metal NPs.

Main Methods:

  • Review of literature on metallic NPs (gold, silver, magnetic, titanium, cerium).
  • Analysis of properties enabling blood-brain barrier (BBB) traversal.
  • Examination of applications in disrupting protein aggregates and cancer cells.

Main Results:

  • Metallic NPs can be engineered for drug loading, contrast agents, and targeting.
  • Gold and silver NPs utilize surface plasmon resonance; magnetic NPs respond to magnetic fields.
  • NPs demonstrate BBB penetration and interaction with CNS components.

Conclusions:

  • Metallic NPs hold significant promise for neurological disorder diagnosis and therapy.
  • Further research is needed to overcome barriers to clinical translation.
  • Understanding their incorporation and physiological effects is crucial for safe application.