Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

285
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
285
Seizures: Classification01:13

Seizures: Classification

600
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
600
Epistasis Analysis01:09

Epistasis Analysis

5.2K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.2K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
Overview of Synapses01:25

Overview of Synapses

3.0K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
3.0K
Narcolepsy01:07

Narcolepsy

201
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
201

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Education Research: Educational Informatics: Characterizing Child Neurology Resident Clinical Experiences Using Electronic Health Record Data.

Neurology. Education·2026
Same author

<i>RAI1</i> safeguards fidelity and tempo of human neurodevelopmental gene expression.

bioRxiv : the preprint server for biology·2026
Same author

L-type voltage-gated Ca<sup>2+</sup> channels control T cell killing via non-canonical Hedgehog signalling.

EMBO reports·2026
Same author

Genome sequencing boosts diagnostic yield for the developmental and epileptic encephalopathies.

medRxiv : the preprint server for health sciences·2026
Same author

High-resolution single-cell mapping of clonal hematopoiesis and structural variation in aplastic anemia.

Nature genetics·2026
Same author

American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy.

Epilepsy currents·2026
Same journal

Leveraging Next-Generation Phenotyping in Dysmorphology to Support Variant Interpretation in Mowat-Wilson Syndrome.

Neurology. Genetics·2026
Same journal

Duchenne Muscular Dystrophy and Delandistrogene Moxeparvovec Gene Therapy in Children: A Systematic Review and Meta-Analysis.

Neurology. Genetics·2026
Same journal

Preparing Amyotrophic Lateral Sclerosis Clinics to Provide Longitudinal Care for Individuals Carrying ALS Risk Variants.

Neurology. Genetics·2026
Same journal

Erratum: NNZ-2591 in Children and Adolescents With Phelan-McDermid Syndrome: Single-Group, Open-Label, Phase 2 Trial Results.

Neurology. Genetics·2026
Same journal

Expanding the Spectrum of <i>BCAP31</i>-Associated Diseases: Early-Onset Parkinson Disease.

Neurology. Genetics·2026
Same journal

Cognitive Decline, Neurologic Involvement, and Neonatal Crisis in <i>ABCC9</i>-Related Intellectual Disability and Myopathy Syndrome.

Neurology. Genetics·2026
See all related articles

Related Experiment Video

Updated: Sep 15, 2025

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.7K

The Association Between Sleep Phenotypes and Epilepsy Genes.

Jonathan Read Gaillard1, Gita Gupta2,3, Heather C Mefford4

  • 1Division of Pediatric Neurology, Department of Pediatrics, University of Michigan, Ann Arbor, MI.

Neurology. Genetics
|July 15, 2025
PubMed
Summary
This summary is machine-generated.

Genetic links between epilepsy and sleep disorders were identified. These shared genetic factors are primarily associated with brain development and neuronal function, highlighting the brain

More Related Videos

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

518
Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.1K

Related Experiment Videos

Last Updated: Sep 15, 2025

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture
09:06

Manipulation of Epileptiform Electrocorticograms ECoGs and Sleep in Rats and Mice by Acupuncture

Published on: December 22, 2016

9.7K
Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

518
Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
10:25

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

6.1K

Area of Science:

  • Neurogenetics
  • Sleep Science
  • Epilepsy Research

Background:

  • The relationship between sleep and epilepsy is complex and bidirectional.
  • Understanding the genetic underpinnings of this connection is crucial for developing targeted therapies.
  • Previous research suggests a potential overlap in genetic factors influencing both conditions.

Purpose of the Study:

  • To investigate the genetic mechanisms underlying the relationship between sleep and epilepsy.
  • To identify specific genes and biological pathways associated with both epilepsy and sleep phenotypes.
  • To determine the specificity of these genetic links by comparing them with other neurological diseases.

Main Methods:

  • Genome-wide association studies (GWAS) were used to identify genetic loci associated with sleep phenotypes.
  • Epilepsy genes were compared with a random set of genes to assess the enrichment of sleep-associated variants.
  • Pathway analysis was performed on genes implicated in both epilepsy and sleep phenotypes.
  • Comparative analysis included genes from other central nervous system (CNS) diseases and various CNS cell types.

Main Results:

  • A significant proportion of epilepsy genes (8.1%) were found to be associated with sleep phenotypes, a 2.7-fold increase compared to random gene sets (3%).
  • Genes linked to both epilepsy and sleep were enriched in pathways related to brain development and neuronal function.
  • Genetic links to sleep phenotypes were observed in other CNS diseases but not in peripheral nervous system diseases.
  • Genes expressed in neurons, astrocytes, and oligodendrocytes showed a strong association with sleep phenotypes, unlike genes in microglia or endothelial cells.

Conclusions:

  • Epilepsy and sleep phenotypes share common genetic links, extending to other CNS disorders and specific brain cell types.
  • The genetic basis of sleep regulation is likely influenced by genes crucial for brain function.
  • These findings provide a foundation for understanding the genetic architecture of sleep disturbances in epilepsy and other neurological conditions.