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Intrathoracic Extrapulmonary Pleomorphic Liposarcoma: A Rare Presentation.
Peter N Rodenko1, Josh S Elefteratos2, Colton A Herrell1
1Medicine, St. George's University School of Medicine, St. George, GRD.
Cureus
|July 15, 2025
Summary
A rare, aggressive pleomorphic liposarcoma (PL) was found in a young adult
Area of Science:
- Oncology
- Pathology
- Radiology
Background:
- Liposarcoma (LPS) is a malignant mesenchymal neoplasm.
- Pleomorphic liposarcoma (PL) is a rare, aggressive subtype, typically affecting older adults in the extremities.
- Primary thoracic PL in young adults is exceptionally rare.
Observation:
- A 28-year-old male presented with shortness of breath and thoracic pain.
- Imaging revealed a large, intrathoracic, extrapulmonary mass.
- Histopathology confirmed high-grade pleomorphic liposarcoma.
Findings:
- The tumor was unusual due to the patient's young age and thoracic location.
- It presented without extensive lung invasion or metastasis.
- The case highlights the rarity of primary thoracic pleomorphic liposarcoma in young adults.
Implications:
- This case underscores the diagnostic and therapeutic challenges of rare liposarcoma subtypes.
- It emphasizes the need for further research into subtype-specific treatment strategies for pleomorphic liposarcoma.
- Multimodal management is crucial for this aggressive cancer, despite literature deficits.
Keywords:
intrathoracic extrapulmonary liposarcomaintrathoracic extrapulmonary pleomorphic liposarcomaintrathoracic pleomorphic liposarcomaliposarcomapleomorphic intrathoracic extrapulmonary liposarcomapleomorphic liposarcomapleural liposarcomarare presentation pleomorphic liposarcomayoung adult liposarcomayoung adult pleomorphic liposarcoma
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