Related Experiment Video
Updated: Sep 15, 2025
Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Development and Content of Core Outcome Sets in Neonatology-A Scoping Review
Ilari Kuitunen1,2, Panu Kiviranta1,3, Marjut Haapanen4
1Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
Aim:
To identify subgroups of neonates for whom core outcome sets (COS) have been developed, the outcomes that were included and the methods used in their formulation.
Methods:
We performed a scoping review and searched databases in April 2025 for published COS. We included COS that reported neonatal outcomes, even when the original interventions targeted pregnant individuals. Methods of COS development and the included outcomes were extracted for descriptive analysis.
Results:
A total of 363 abstracts were screened and 34 COS studies included for analysis. The most used methods were modified Delphi and Delphi consensus methods, consisting of a median of three rounds and a consensus meeting. Overall, a total of 62 distinct neonatal outcomes were proposed. The five most commonly included outcomes were neonatal mortality, preterm birth, birth weight, need for neonatal intensive care unit admission and neurodevelopment.
Conclusion:
We found that the neonatal core outcome sets had clear heterogeneity in their selected outcomes. Future primary studies and evidence reviews should aim to focus on including important outcomes, when possible, to improve consistency in reporting.
Protocol Registration:
Protocol was registered to open science framework and is available from https://osf.io/yngbd/.
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