Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Homoharringtonine: a phase I evaluation.

J A Stewart, I H Krakoff

    Investigational New Drugs
    |January 1, 1985
    PubMed
    Summary

    Homoharringtonine shows anti-leukemia effects but causes hypotension and cardiac issues. Continuous infusion increases myelosuppression, requiring further study for safe use in cancer treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preterm infant with necrotizing enterocolitis and arteritis secondary to streptococcus gallolyticus subspecies pasteurianus.

    Journal of neonatal-perinatal medicine·2024
    Same author

    Prolonged cycling lowers subsequent running mechanical efficiency in collegiate triathletes.

    BMC sports science, medicine & rehabilitation·2022
    Same author

    Dichotomy between Regulation of Coral Bacterial Communities and Calcification Physiology under Ocean Acidification Conditions.

    Applied and environmental microbiology·2021
    Same author

    Noninvasive Neuromonitoring of Hypothermic Circulatory Arrest in Aortic Surgery.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2019
    Same author

    CO<sub>2</sub> storage and release in the deep Southern Ocean on millennial to centennial timescales.

    Nature·2018
    Same author

    Long-Term Survival and Quality of Life After Hypothermic Circulatory Arrest in Aortic Surgery.

    Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2018

    Area of Science:

    • Oncology
    • Pharmacology

    Background:

    • Homoharringtonine, a Cephalotaxine ester, exhibits experimental antineoplastic and anti-leukemia activity.
    • Previous studies suggest potential in cancer treatment, particularly leukemia.

    Purpose of the Study:

    • To evaluate the safety and tolerability of homoharringtonine in a Phase I clinical trial.
    • To determine the dose-limiting toxicities and maximum tolerated dose (MTD) of homoharringtonine.
    • To compare the effects of bolus versus continuous intravenous infusion.

    Main Methods:

    • A Phase I clinical trial involving daily bolus intravenous injections of homoharringtonine for 5 days.
    • Assessment of dose-limiting toxicities, including hypotension and cardiac irritability.
    • Comparison with a 5-day continuous intravenous infusion regimen.

    Main Results:

    • The dose-limiting toxicity was hypotension, with an MTD of 3.5 mg/m²/day for 5 days via bolus injection.
    • Cardiac irritability, ventricular, and atrial dysrhythmias were observed.
    • Continuous infusion led to more pronounced myelosuppression and tolerable hypotension, with significant reductions in white blood cell and platelet counts at 3.5 mg/m²/day.

    Conclusions:

    • Homoharringtonine demonstrates anti-leukemia potential but is associated with significant cardiovascular and hematologic toxicities.
    • Continuous infusion may enhance myelosuppression but requires careful monitoring for hypotension.
    • Further investigation into cardiovascular effects and Phase II trials with continuous infusion are warranted.

    Related Experiment Videos