Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

673
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
673
Amyloid Fibrils03:03

Amyloid Fibrils

9.9K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.9K
Language and Cognition01:27

Language and Cognition

450
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
450
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

263
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
263
Dementia01:30

Dementia

169
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
169

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The arsenic-Alzheimer's disease link: Emerging evidence and unanswered questions.

Journal of Alzheimer's disease : JAD·2026
Same author

Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells.

Lab on a chip·2024
Same author

Obesity Accelerates Alzheimer-Related Pathology in <i>APOE4</i> but not <i>APOE3</i> Mice.

eNeuro·2017

Related Experiment Video

Updated: Sep 15, 2025

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.8K

The gap between amyloid pathology and cognition.

V Alexandra Moser1

  • 1Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Journal of Alzheimer'S Disease : JAD
|July 15, 2025
PubMed
Summary

Researchers found that removing WDR23 in Alzheimer's disease (AD) mice improved memory but worsened AD pathology. This suggests a complex relationship between brain function and disease markers in AD.

Keywords:
Alzheimer's diseaseNrf2amyloid-βcognitionneuroinflammationoxidative stress

More Related Videos

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
10:19

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Published on: August 14, 2016

9.4K
Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections
07:28

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

4.0K

Related Experiment Videos

Last Updated: Sep 15, 2025

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

10.8K
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
10:19

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Published on: August 14, 2016

9.4K
Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections
07:28

Full- versus Sub-Regional Quantification of Amyloid-Beta Load on Mouse Brain Sections

Published on: May 19, 2022

4.0K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurodegenerative Diseases

Background:

  • Nuclear factor erythroid 2-related factor 2 (Nrf2) is crucial for brain protection against oxidative stress.
  • Nrf2 levels are reduced in Alzheimer's disease (AD) patients, identifying it as a therapeutic target.
  • WDR23 was previously identified as a novel regulator of Nrf2.

Purpose of the Study:

  • To investigate the role of WDR23 in a mouse model of Alzheimer's disease.
  • To examine the effects of WDR23 knockout on cognitive function and AD-like pathology.

Main Methods:

  • Utilized a 3xTg-AD mouse model with WDR23 knockout.
  • Assessed spatial working memory performance.
  • Measured markers of AD-like pathology.

Main Results:

  • WDR23 knockout in 3xTg-AD mice led to improved spatial working memory.
  • Concurrently, WDR23 knockout increased a measure of AD-like pathology in these mice.
  • The findings suggest a complex interplay between cognitive function and amyloid pathology.

Conclusions:

  • WDR23 plays a significant role in modulating cognitive function and neuropathology in the context of AD.
  • The relationship between cognitive deficits and amyloid pathology in AD is not straightforward.
  • Further research is needed to elucidate the precise mechanisms by which WDR23 influences AD progression.