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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Structure and Function of Platelets01:18

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Sep 15, 2025

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

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Immune response to platelet transfusions.

Rachael P Jackman1,2, Kimberly A Thomas3,4

  • 1Vitalant Research Institute.

Current Opinion in Hematology
|July 15, 2025
PubMed
Summary
This summary is machine-generated.

Platelet transfusions can cause immune responses due to donor antigens and mediators. Understanding these mechanisms can lead to interventions preventing alloimmunization and improving patient outcomes.

Keywords:
alloimmunizationimmunomodulationinflammationplatelet transfusion

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Area of Science:

  • Immunology
  • Transfusion Medicine

Background:

  • Platelet transfusions expose recipients to donor alloantigens, leukocytes, and immune mediators.
  • Donor platelets influence the recipient's inflammatory profile.

Purpose of the Study:

  • Review recent advancements in understanding immune responses to platelet transfusion.
  • Explore mechanisms regulating the immune response to platelet transfusion.

Main Methods:

  • Review of recent developments in the field.
  • Analysis of findings from animal models.

Main Results:

  • Animal models reveal mechanisms of alloimmune response to platelet transfusion.
  • Recipient health influences the alloimmune response.
  • Platelets actively participate in immunity, impacting transfusion outcomes.
  • Product collection, processing, and storage affect immunological profiles.

Conclusions:

  • Platelet transfusion offers benefits but carries risks of alloimmunization and immune-mediated adverse reactions.
  • Further research can identify interventions to prevent alloimmunization.
  • Identifying optimal platelet products for specific patient populations is crucial.