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Updated: Sep 15, 2025

Augmenting Large Language Models via Vector Embeddings to Improve Domain-Specific Responsiveness
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Automated assignment grading with large language models: insights from a bioinformatics course.

Pavlin G Poličar1, Martin Špendl1, Tomaž Curk1

  • 1Faculty of Computer and Information Science, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia.

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|July 15, 2025
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Summary
This summary is machine-generated.

Large language models (LLMs) can effectively grade student assignments, providing feedback comparable to human teaching assistants. This technology offers a scalable solution for personalized education, with open-source LLMs proving as capable as commercial options.

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Area of Science:

  • Educational Technology
  • Artificial Intelligence in Education
  • Bioinformatics Education

Background:

  • Individualized feedback is crucial for student learning but challenging to provide at scale.
  • Large language models (LLMs) offer a potential solution for efficient, personalized feedback.
  • Evaluating LLM effectiveness in real educational settings is essential.

Purpose of the Study:

  • To evaluate the practical effectiveness of LLM-based grading for written assignments.
  • To compare the grading accuracy and feedback quality of LLMs against human teaching assistants (TAs).
  • To assess the performance of both commercial and open-source LLMs.

Main Methods:

  • A practical evaluation was conducted in an "Introduction to Bioinformatics" course with over 100 students.
  • Students' text-based answers were graded using LLMs, with a subset receiving feedback from both LLMs and human TAs in a blind study.
  • Six commercial and open-source LLMs were systematically evaluated and compared to human TA performance.

Main Results:

  • LLMs, when prompted effectively, achieved grading accuracy and feedback quality comparable to human TAs.
  • Open-source LLMs demonstrated performance on par with commercial LLMs.
  • Student feedback quality ratings were similar for LLM-generated and human-generated feedback.

Conclusions:

  • LLMs are a viable tool for grading written assignments, offering scalable and high-quality feedback.
  • Open-source LLMs provide a cost-effective and privacy-preserving alternative for educational institutions.
  • LLM-based grading can reduce instructor workload while enhancing student learning experiences.