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Updated: Sep 15, 2025
10:27
In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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Dynamic modifications of circular RNAs drive oncogenesis
Jiaojiao Dai1,2, Zhe Wang1,2, Xiaoxun Cheng3
1School of Pharmacy and Science, Anhui Medical University, Hefei, China.
Epigenomics
|July 15, 2025
Summary
Circular RNAs (circRNAs) modifications are crucial in cancer progression. Targeting these RNA epigenetic modifications offers new avenues for refractory cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Epigenetics
Background:
- Circular RNAs (circRNAs) are non-coding RNAs involved in cancer progression.
- Post-transcriptional modifications like m6A, m1A, m5C, ac4C, and m7G are found on circRNAs.
- These modifications influence circRNA biogenesis, metabolism, stability, and function in cancer.
Purpose of the Study:
- To review and synthesize current research on circRNA modifications in various cancers.
- To highlight the role of circRNA modifications in cancer progression and potential therapeutic strategies.
- To discuss emerging technologies for detecting and targeting modified circRNAs.
Main Methods:
- Systematic literature search of PubMed and Web of Science databases.
- Review and synthesis of studies focusing on circRNA modifications in cancer.
- Analysis of innovations in detection techniques and bioinformatics algorithms.
Main Results:
- CircRNA modifications significantly impact cancer development and progression.
- Crosstalk between circRNA and mRNA epigenetic modifications provides new therapeutic insights.
- Advanced detection methods and AI-based algorithms are improving the study of modified circRNAs.
Conclusions:
- CircRNA modifications are critical regulators in cancer, offering potential therapeutic targets.
- Targeting circRNA modifications, alongside mRNA epigenetics, presents a promising approach for precision cancer therapy.
- Future research directions include developing clinical protocols for targeting circRNA modifications in refractory malignancies.
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