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Updated: Sep 15, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Dynamic modifications of circular RNAs drive oncogenesis

Jiaojiao Dai1,2, Zhe Wang1,2, Xiaoxun Cheng3

  • 1School of Pharmacy and Science, Anhui Medical University, Hefei, China.

Epigenomics
|July 15, 2025
PubMed

Insights

Circular RNAs (circRNAs) modifications are crucial in cancer progression. Targeting these RNA epigenetic modifications offers new avenues for refractory cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Circular RNAs (circRNAs) are non-coding RNAs involved in cancer progression.
  • Post-transcriptional modifications like m6A, m1A, m5C, ac4C, and m7G are found on circRNAs.
  • These modifications influence circRNA biogenesis, metabolism, stability, and function in cancer.

Purpose of the Study:

  • To review and synthesize current research on circRNA modifications in various cancers.
  • To highlight the role of circRNA modifications in cancer progression and potential therapeutic strategies.
  • To discuss emerging technologies for detecting and targeting modified circRNAs.

Main Methods:

  • Systematic literature search of PubMed and Web of Science databases.
  • Review and synthesis of studies focusing on circRNA modifications in cancer.
  • Analysis of innovations in detection techniques and bioinformatics algorithms.

Main Results:

  • CircRNA modifications significantly impact cancer development and progression.
  • Crosstalk between circRNA and mRNA epigenetic modifications provides new therapeutic insights.
  • Advanced detection methods and AI-based algorithms are improving the study of modified circRNAs.

Conclusions:

  • CircRNA modifications are critical regulators in cancer, offering potential therapeutic targets.
  • Targeting circRNA modifications, alongside mRNA epigenetics, presents a promising approach for precision cancer therapy.
  • Future research directions include developing clinical protocols for targeting circRNA modifications in refractory malignancies.
Keywords:
CircRNAscancer therapycrosstalkdetection techniquesepigenetic modifications

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