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The Association Between the Hemoglobin Glycation Index and Cardiometabolic Diseases: A Mini-Review

Qing-Yun Wu1,2, Li-Rong Mo1, Jing Nan3

  • 1Department of Cardiology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|July 15, 2025
PubMed

Insights

The hemoglobin glycation index (HGI) offers better long-term glycemic control assessment than HbA1c. Elevated HGI is linked to cardiometabolic diseases, aiding clinical risk prediction.

Area of Science:

  • Endocrinology and Metabolism
  • Cardiovascular Medicine
  • Clinical Biochemistry

Background:

  • Hemoglobin glycation index (HGI) is a biomarker for long-term glycemic control.
  • HGI provides a more comprehensive assessment than glycated hemoglobin (HbA1c).
  • Elevated HGI correlates with cardiometabolic diseases (CMDs).

Purpose of the Study:

  • To review the clinical utility of HGI in various cardiometabolic conditions.
  • To provide clinicians with an enhanced framework for disease stratification and management.
  • To explore HGI's role in coronary artery disease, hypertension, heart failure, diabetes mellitus, serum uric acid levels, and nonalcoholic fatty liver disease.

Main Methods:

  • Systematic review of current evidence on HGI.
  • Synthesis of studies evaluating HGI in relation to CMDs.
  • Analysis of HGI's prognostic and therapeutic implications.

Main Results:

  • HGI is a significant predictor of cardiometabolic disease incidence.
  • Evidence supports HGI's utility across diverse conditions including CAD, HF, DM, and NAFLD.
  • HGI aids in precise disease stratification and therapeutic optimization.

Conclusions:

  • HGI is a valuable biomarker for assessing long-term glycemic control and CMD risk.
  • Integrating HGI into clinical practice can enhance patient management and prognosis.
  • Further research into HGI's applications is warranted.

Keywords:
cardiovascular diseasesglycated hemoglobinhemoglobin glycation indexinsulin resistancemetabolic disorders

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