Related Experiment Video
Updated: Sep 15, 2025

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
Published on: May 4, 2020
Implementation of Less Invasive Surfactant Administration (LISA) for Preterm Neonates with Respiratory Distress
Triptee Agrawal1, Mandula Phani Priya1, Venkataseshan Sundaram2
1Division of Neonatology, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Objectives:
To initiate less invasive surfactant administration (LISA) in authors' unit using a quality improvement (QI) approach and increase LISA rates by 50% over 10 mo period.
Methods:
The authors adopted a QI methodology to address this issue. The proportion of surfactant administration done by the LISA method was the primary outcome indicator. Focused group discussions were conducted with doctors and nurses during the initial phase to identify the root causes. Meetings were conducted where team members were given descriptions of the insertion method, complications and precautions to be taken. All the members were trained to use LISA on mannequins in a simulation lab. They were also trained regarding the fixation of continuous positive airway pressure (CPAP), monitoring of complications and correction steps. Multiple Plan-Do-Study-Act (PDSA) cycles were implemented. A standard operating policy was developed, and all babies requiring surfactant were administered surfactant with the LISA technique.
Results:
Over the 10 mo, the proportion of neonates who received surfactant via the LISA method increased from 0 to 90%. Complications such as desaturation (74%), surfactant reflux (32.1%), bradycardia (25%), and unilateral administration of surfactant (26.7%), which were initially observed, gradually decreased to 7.4%, 3.7%, 7.4%, and 7.4%, respectively.
Conclusions:
Utilising QI tools, the authors achieved an increase in the rate of surfactant administration by the LISA method by more than 50%.
More Related Videos
04:21A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease
Published on: August 4, 2021
06:22Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Related Concept Videos
Breathing
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Pulmonary Cycle: Exhalation
Endotracheal Intubation I: Procedure
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
Cardiopulmonary Resuscitation II: ACLS Airway Management
Assessment of Respiration
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like...