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The role of long noncoding RNA SNHG29 in malignant tumors

Tingcheng Bu1, Wendong Gu2, Yingjie Shao3

  • 1Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, China.

Discover Oncology
|July 15, 2025
PubMed

Insights

Small nucleolar RNA host gene 29 (SNHG29) is a long noncoding RNA (lncRNA) implicated in various cancers. Research highlights its role in tumor progression and potential as a diagnostic and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer.
  • Small nucleolar RNA host gene 29 (SNHG29) shows aberrant expression in multiple malignancies.

Purpose of the Study:

  • To review current research on SNHG29 expression, functions, and regulatory pathways in cancer.
  • To synthesize insights into SNHG29's contribution to oncogenic processes.

Main Methods:

  • Literature review of recent studies on SNHG29 in malignancies.
  • Analysis of SNHG29's involvement in cell proliferation, migration, EMT, chemoresistance, and immunosuppression.
  • Examination of SNHG29's function as a competing endogenous RNA (ceRNA) and its associated signaling pathways.

Main Results:

  • SNHG29 contributes to key oncogenic processes including proliferation, migration, and chemoresistance.
  • SNHG29 acts as a ceRNA, regulating tumor progression through miRNA-mRNA interactions.
  • SNHG29 influences critical signaling pathways like ATR-Chk1, PI3K-AKT, and Wnt-β-catenin.

Conclusions:

  • SNHG29 plays a significant role in diverse cancer types.
  • SNHG29 is a potential diagnostic and prognostic biomarker for malignancies.
  • SNHG29 represents a promising molecular target for cancer therapy.
Keywords:
BiomarkerHuman cancerLong noncoding RNAPrognosisSNHG29

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