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07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
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Association Between Elevated Lipoprotein(a) and Diastolic Dysfunction: A Retrospective Cohort Study.
Hesham Sheashaa1, Kamal Awad1, Arshad Mohammed2
1Department of Cardiovascular Medicine, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.
Summary
Elevated Lipoprotein(a) [Lp(a)] was not linked to diastolic dysfunction (DD) in patients with preserved ejection fraction (EF). Traditional cardiovascular risk factors, not Lp(a), were associated with DD.
Area of Science:
- Cardiology
- Cardiovascular Research
- Clinical Medicine
Background:
- Lipoprotein(a) [Lp(a)] is implicated in myocardial fibrosis and endothelial dysfunction, potential contributors to diastolic dysfunction (DD).
- This study investigates the association between elevated Lp(a) levels (≥ 50 mg/dL) and DD in patients with preserved ejection fraction (EF).
Purpose of the Study:
- To assess the relationship between elevated Lipoprotein(a) and diastolic dysfunction in patients with preserved ejection fraction.
- To identify factors associated with diastolic dysfunction in this patient population.
Main Methods:
- Analysis of 1492 adult patients with Lp(a) measurements and echocardiograms.
- Diastolic dysfunction defined by ≥ 3 abnormal echocardiographic parameters.
- Logistic regression analysis adjusted for potential confounders.
Main Results:
- Elevated Lp(a) (≥ 50 mg/dL) was not associated with diastolic dysfunction (aOR: 0.89, 95% CI: 0.49-1.54).
- Age, hypertension, diabetes mellitus, and pre-existing cardiovascular diseases were significantly associated with DD.
- Statin therapy showed a reduced risk of DD (aOR: 0.51).
Conclusions:
- Lipoprotein(a) is not associated with diastolic dysfunction in patients with preserved ejection fraction.
- Management of traditional cardiovascular risk factors is crucial for addressing diastolic dysfunction in this cohort.
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