Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Performance differences between addicts and non-addicts.

S Rothenberg, S Schottenfeld, R E Meyer

    Psychopharmacology
    |May 9, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Thoracoscopic Resection of Pulmonary Lesions in Israel: The Mentorship Approach.

    Journal of Indian Association of Pediatric Surgeons·2024
    Same author

    Veterinary clinical research or experiments on pets.

    Veterinary anaesthesia and analgesia·2023
    Same author

    Fast neutron activation of ubiquitous materials.

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2022
    Same author

    Vanishing congenital lung malformations: What is the incidence of true regression?

    Journal of neonatal-perinatal medicine·2021
    Same author

    Der Anaesthesist·2021
    Same author

    [Anesthesia in patients with dopa-responsive dystonia (Segawa syndrome) : Presentation of the pathophysiology, clinical picture and approach based on two case reports].

    Der Anaesthesist·2020
    Same journal

    Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

    Psychopharmacology·2026
    Same journal

    Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

    Psychopharmacology·2026
    Same journal

    Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

    Psychopharmacology·2026
    Same journal

    Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

    Psychopharmacology·2026
    Same journal

    Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

    Psychopharmacology·2026
    Same journal

    OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.

    Psychopharmacology·2026
    See all related articles

    Methadone addicts exhibit faster visual reaction times than controls, unaffected by additional methadone. Methadone slows controls

    Area of Science:

    • Neuroscience
    • Psychopharmacology
    • Addiction Research

    Background:

    • Opioid addiction significantly impacts cognitive functions, including reaction time and attention.
    • Understanding the neurobiological effects of methadone is crucial for addiction treatment.
    • Previous research indicates altered performance on cognitive tasks in individuals with substance use disorders.

    Purpose of the Study:

    • To investigate visual reaction time and attention in methadone addicts compared to non-addict controls.
    • To examine the acute effects of methadone on cognitive performance in both groups.
    • To explore potential differences in visual sensitivity as an explanation for observed performance variations.

    Main Methods:

    • Participants (methadone addicts and non-addict controls) underwent simple visual reaction time and vigilance tests.

    Related Experiment Videos

  • Testing was conducted before and after administration of up to 10 mg of methadone.
  • Motivation was assessed by offering monetary incentives for speed.

    • Main Results:

    • Addicts demonstrated faster pre-drug reaction times than controls, with no significant pre-drug attention differences.
    • Methadone did not alter addict performance on reaction time or attention tasks.
    • Methadone dose-dependently slowed control reaction times, without impairing attention.

    Conclusions:

    • Faster reaction times in addicts are not attributable to motivation or attention differences.
    • Methadone's acute effects on controls' reaction time are independent of attention.
    • Hypothesized changes in visual sensitivity may explain performance differences between addicts and controls.