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Updated: Sep 15, 2025
Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
Published on: February 26, 2015
Clinical application of artificial dermis in pediatric deep wounds
Weiqing Li1, Shuaidan Zeng1, Xiaodi Chen1
1Department of Pediatric Orthopedics, Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, Guangdong, China.
Insights
Artificial dermis effectively treats deep wounds in children, promoting healing and potentially avoiding skin grafts. Careful infection control is crucial for successful outcomes in pediatric wound repair.
Area of Science:
- Regenerative Medicine
- Pediatric Surgery
- Wound Healing
Background:
- Artificial dermis is widely used for wound repair with positive results.
- Clinical application in pediatric patients with deep wounds requires further investigation.
Purpose of the Study:
- To evaluate the efficacy and safety of artificial dermis in treating deep wounds in children.
- To assess healing progress, infection rates, and the need for secondary skin grafting.
Main Methods:
- Retrospective analysis of 60 pediatric patients treated with Lando bilayer artificial dermis.
- Data collected included wound characteristics, vascularization time, infection, need for skin grafting, and healing duration.
- Two-month follow-up to evaluate wound healing progress.
Main Results:
- 60 pediatric patients (34 male, 26 female; average age 54.7 months) with trauma or burn wounds were analyzed.
- 26.7% healed with artificial dermis alone, while 68.3% required secondary skin grafting.
- 5.0% developed localized infections, successfully managed with treatment and repair.
Conclusions:
- Artificial dermis is a safe and effective option for pediatric deep wound management.
- Vigilant infection control is paramount for optimal outcomes.
- Artificial dermis can promote epithelialization, potentially reducing the need for skin grafts.
Background:
The application of artificial dermis in wound repair has been widespread and yielded positive outcomes, yet there has been relatively less emphasis on its clinical application in pediatric patients. This study aims to investigate the use of artificial dermis in children with deep wounds.
Methods:
A retrospective analysis was conducted on patients who underwent initial Lando bilayer artificial dermis implantation treatment between November 2021 and January 2024. The recorded and analyzed data for each case included: age, gender, etiology and characteristics of the wound, timing of artificial dermis vascularization, occurrence of infection, need for a secondary skin graft, and duration of wound healing, etc. A clinical follow-up was performed two months after discharge with the primary objective being to evaluate the healing progress of the original wounds.
Results:
A total of 60 cases were involved in this study (34 males and 26 females). The average age was 54.7 ± 40.8 months. The causes of wounds were divided into two categories: trauma (28 cases) and burn damage (32 cases). The size of the wounds was 15.0(5.1, 34.0) cm2. Following the implantation of artificial dermis, 16 cases (26.7 %) exhibited >70 % wound direct epithelialization area and subsequently healed with dressing change, with the healing time of 5-11(7.81±1.5) days. In 41 cases (68.3 %) <70 % wound direct epithelialization area was observed, necessitating an additional skin graft to close the wound. The vascularization time of the 41 cases (68.3 %) took 6-15 days (8.7 ± 2.3d). The wound healing time was 12-31 (15.6 ± 3.9) days. The remaining 3 cases (5.0 %) developed localized infection, which were managed by treating the infection first followed by either changing the dressing or transferring local flaps for repair. Infection-free wounds recovered effectively without any new ulcers during the two-month follow-up period.
Conclusion:
Pediatric deep wounds can be effectively and safely managed using artificial dermis; however, meticulous attention must be given to infection control. Artificial dermis holds the potential to facilitate epithelialization, thereby obviating the need for skin grafting.
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