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Updated: Jul 16, 2026
07:07
Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
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Polydatin as a Potential Therapeutic in Pediatric Intestinal Volvulus: Evidence from an Experimental I/R Injury Model
Gökhan Arkan1, Betül Öğüt2, Aylar Poyraz2
1Department of Pediatric Surgery, Gazi University, Ankara, Turkey.
Summary
Polydatin protects against small bowel volvulus by reducing oxidative stress and tissue damage. This natural compound shows therapeutic potential for intestinal ischemia-reperfusion injury.
Area of Science:
- Biochemistry
- Pathology
- Pharmacology
Background:
- Small bowel volvulus causes intestinal ischemia-reperfusion (I/R) injury, a condition with high mortality.
- Polydatin, a natural polyphenol, possesses known anti-inflammatory and antioxidant properties.
Purpose of the Study:
- To investigate the protective effects of polydatin against I/R injury.
- To evaluate polydatin's efficacy in an experimental small bowel volvulus rat model.
Main Methods:
- Rats were divided into four groups: Sham, Polydatin, I/R, and Treatment (polydatin before reperfusion).
- Intestinal segments underwent 2 hours of ischemia followed by 2 hours of reperfusion.
- Biochemical markers (TAS, TOS, OSI) and histopathological damage were analyzed.
Main Results:
- Treatment with polydatin significantly increased serum total antioxidant status (TAS).
- Polydatin significantly reduced serum total oxidant status (TOS) and tissue oxidative stress index (OSI).
- Histopathological analysis showed reduced tissue damage in the polydatin-treated group compared to the I/R group.
Conclusions:
- Polydatin demonstrates protective effects against ischemia-reperfusion injury in small bowel volvulus.
- The mechanism involves reducing oxidative stress and mitigating histopathological damage.
- Polydatin holds therapeutic potential for I/R injury, warranting further clinical investigation.
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