Color K-edge angiography with a dedicated gadolinium-based contrast agent for spectral photon-counting computed
Christian Alejandro Hernandez-Fajardo1, François Lux2, Tristan Doussineau3
1University of Lyon, INSA-Lyon, Université Claude Bernard Lyon 1, UJM-Saint Etienne, CNRS, Inserm, CREATIS UMR 5220, U1206, 69621, 69100 Villeurbanne, France.
Gadolinium-based ultrasmall rigid platforms (USRPs) are feasible for angiography imaging using spectral photon-counting CT. This study demonstrates their potential as contrast media for advanced CT applications.
Area of Science:
- Medical Imaging
- Radiology
- Biomedical Engineering
Background:
- Spectral photon-counting CT (SPCCT) offers advanced imaging capabilities.
- Gadolinium (Gd)-based contrast agents are crucial for CT angiography.
- Ultrasmall rigid platforms (USRPs) represent a novel class of Gd-based contrast agents.
Purpose of the Study:
- To evaluate the feasibility of using Gd-based USRPs for angiography.
- To assess USRPs with color K-edge imaging and SPCCT technology.
- To compare USRPs with a conventional agent in a rabbit model.
Main Methods:
- Ten atherosclerotic rabbits were intravenously administered USRP solution.
- A subset of rabbits received gadoteric acid for comparison.
- Rabbits underwent imaging using a clinical SPCCT prototype at various time points post-injection.
Main Results:
- Both USRP and gadoteric acid achieved matching first-pass signals for angiography.
- USRP showed a minimal but significant increase in average signal in vessels compared to gadoteric acid.
- Similar renal excretion profiles were observed for both Gd-based agents.
Conclusions:
- Gd-based USRPs are feasible for color K-edge angiography imaging.
- USRPs are viable contrast media candidates for SPCCT applications.
- This technology holds promise for emerging CT applications.
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