Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interspike interval dependency from arterial chemoreceptors.

D F Donnelly, W F Nolan, E J Smith

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |November 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Building a Self-Sustaining Psychology Research Team in Academic Medicine: A Multi-Tiered Mentorship Model.

    Journal of clinical psychology in medical settings·2024
    Same author

    Use of enhanced stent visualisation compared to angiography alone to guide percutaneous coronary intervention.

    International journal of cardiology·2020
    Same author

    Genome-wide transcriptome analysis reveals equine embryonic stem cell-derived tenocytes resemble fetal, not adult tenocytes.

    Stem cell research & therapy·2020
    Same author

    Eptifibatide is associated with significant cost savings and similar clinical outcomes to abciximab when used during primary percutaneous coronary intervention for ST-elevation myocardial infarction: An observational cohort study of 3863 patients.

    JRSM cardiovascular disease·2017
    Same author

    Jupiter's magnetosphere and aurorae observed by the Juno spacecraft during its first polar orbits.

    Science (New York, N.Y.)·2017
    Same author

    Guillain Barré Syndrome is induced in Non-Obese Diabetic (NOD) mice following Campylobacter jejuni infection and is exacerbated by antibiotics.

    Journal of autoimmunity·2016
    Same journal

    Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    See all related articles

    Carotid body impulses are not random. Analysis reveals a negative feedback system within the carotid body, limiting variations in firing frequency for chemoreceptor afferents.

    Area of Science:

    • Neuroscience
    • Physiology
    • Respiratory Control

    Background:

    • The carotid body is a key chemoreceptor organ sensing blood oxygen and carbon dioxide levels.
    • Its impulse generation has been modeled as a Poisson-type random process.

    Purpose of the Study:

    • To validate the Poisson-type random process characterization of the carotid body impulse generator.
    • To investigate interspike interval dependency in sinus nerve spike trains from chemoreceptive afferents.

    Main Methods:

    • Recorded impulse trains from 15 single chemoreceptive afferents in vivo under hypoxic-hypercapnic conditions.
    • Analyzed approximately 1,000 consecutive interspike intervals per fiber for serial dependence.
    • Compared original spike trains with shuffled control series lacking serial dependence.

    Related Experiment Videos

    Main Results:

    • Original spike trains exhibited significantly negative first-order serial correlation coefficients.
    • Joint interval distributions of original trains showed less variability than shuffled controls.
    • These findings indicate non-random firing patterns in chemoreceptor afferents.

    Conclusions:

    • The carotid body impulse generator does not operate as a simple Poisson-type random process.
    • The observed interspike interval dependency suggests an intrinsic negative feedback mechanism.
    • This feedback system likely regulates and limits variations in the mean firing frequency of chemoreceptors.