Related Experiment Video

Updated: Sep 15, 2025

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants
09:16

Array Comparative Genomic Hybridization Array CGH for Detection of Genomic Copy Number Variants

Published on: February 21, 2015

19.8K

Chromosomal quality control in hPSCs: A practical guide to SNP array analysis with GenomeStudio

Josephine Haake1, Laura Steenpass1,2

  • 1Department of Human and Animal Cell Lines, Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany.

Frontiers in Cell and Developmental Biology
|July 16, 2025
PubMed
Summary

Ensuring chromosomal stability in human pluripotent stem cells (hPSCs) is crucial for reliable research. This guide simplifies SNP array analysis for detecting aberrations, improving quality control workflows for genomic stability.

Keywords:
B-allele frequencyGenomeStudioSNP array analysischromosomal stability in hPSCslog R ratioquality control of hPSCs

More Related Videos

Infinium Assay for Large-scale SNP Genotyping Applications13:33

Infinium Assay for Large-scale SNP Genotyping Applications

Published on: November 19, 2013

39.2K
DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning09:27

DNA Microarrays: Sample Quality Control, Array Hybridization and Scanning

Published on: March 15, 2011

38.1K

Related Concept Videos

Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.9K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.3K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.9K