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Mass Spectrometry: Isotope Effect

Mass Spectrometry: Isotope Effect

Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of a molecule is different depending on the specific isotope of its elements involved. As a result, the mass spectrum of the molecule exhibits peaks from the same fragment at multiple positions. The positions of these mass signals depend on the mass differences between isotopes. Furthermore, the intensity of these signals is dependent on the...

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A New Straightforward Method for Lipophilicity logP Measurement using 19F NMR Spectroscopy

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Published on: January 30, 2019

Advancing Isotope Labeling Technologies at AstraZeneca through Academic-Industrial Collaboration.

Ryan A Bragg¹, Jonas Bergare², Markus Artelsmair²

¹Early Chemical Development, Pharmaceutical Science, R&D, AstraZeneca, Cambridge CB2 0AA, U.K.

ACS Medicinal Chemistry Letters

|July 16, 2025

Summary

Academic-industrial collaborations advanced synthetic methodologies for isotope chemistry. These innovative partnerships yielded new methods successfully applied in an AstraZeneca project, enhancing drug discovery.

Keywords:

Carbonylation Collaboration Isotopes Radiolabeling Tritium

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Area of Science:

Organic Chemistry
Medicinal Chemistry
Isotope Chemistry

Background:

Academic-industrial collaborations are crucial for advancing synthetic chemistry.
AstraZeneca's isotope chemistry team benefits from external partnerships.
Developing novel synthetic routes is key for pharmaceutical research.

Purpose of the Study:

To highlight the impact of academic-industrial collaborations on synthetic methodology.
To showcase innovative isotope chemistry techniques developed through partnerships.
To demonstrate the application of these methods in a pharmaceutical project.

Main Methods:

Review of two specific academic-industrial collaborations.
Analysis of synthetic methodologies developed.
Case study of application within an AstraZeneca project.

Main Results:

Successful development of novel synthetic methodologies.
Effective implementation of these methods in a drug discovery project.
Demonstrated value of collaborative research in isotope chemistry.

Conclusions:

Academic-industrial partnerships accelerate innovation in synthetic and isotope chemistry.
Collaborative efforts lead to practical applications in pharmaceutical development.
These partnerships are vital for advancing AstraZeneca's research capabilities.