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Using Manganese-Enhanced MRI to visualize Magnetogenetic-based Neuromodulation.

Brianna Ricker1, Nir Dayan1, Galit Pelled2,3

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Summary
This summary is machine-generated.

Electromagnetic perceptive gene (EPG) protein activation by electromagnetic fields enhances manganese ion (Mn2+) uptake in cells. This finding supports using manganese-enhanced MRI to monitor EPG

Keywords:
Magnetogeneticsmanganese enhanced MRI (MEMRI)neuromodulation

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Area of Science:

  • Neuroscience
  • Biophysics
  • Molecular Biology

Background:

  • The electromagnetic perceptive gene (EPG) protein is being investigated for its potential as a magnetogenetic tool.
  • Electromagnetic field (EMF) activation of EPG influences intracellular calcium levels.
  • Understanding EPG's interaction with other ions is crucial for its application in neuromodulation.

Purpose of the Study:

  • To investigate the influence of EPG on manganese ion (Mn2+) dynamics.
  • To explore the potential of using manganese-enhanced MRI (MEMRI) to monitor EPG activity.
  • To establish EPG as a magnetogenetic tool for neuromodulation.

Main Methods:

  • HEK293FT cells expressing EPG were treated with manganese chloride (MnCl2) and stimulated with electromagnetic fields.
  • Cell lysates underwent T1 map measurements to quantify intracellular Mn2+ presence.
  • Control experiments were performed to validate EPG's effect on Mn2+ dynamics.

Main Results:

  • Cells expressing EPG exhibited significantly lower T1 values post-stimulation compared to control cells.
  • This indicates increased intracellular Mn2+ uptake in EPG-expressing cells.
  • EMF activation of EPG directly influences Mn2+ dynamics.

Conclusions:

  • Magnetic activation of EPG enhances cellular Mn2+ uptake.
  • EPG's influence on ions relevant to neuronal function is demonstrated.
  • MEMRI can potentially monitor EPG's neuromodulatory activity.