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COOKIE-Pro: Covalent Inhibitor Binding Kinetics Profiling on the Proteome Scale.

Hanfeng Lin1,2,3, Bin Yang1,2, Lang Ding3,4

  • 1The Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, Texas 77030, United States.

Biorxiv : the Preprint Server for Biology
|July 16, 2025
PubMed
Summary

COOKIE-Pro is a new proteomics method to measure covalent inhibitor binding kinetics and selectivity across all proteins. This tool aids in developing more potent and selective covalent drugs.

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