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ESRP1 drives subtype-specific breast cancer progression through ER-regulated transcriptional programs and EMT-related splicing switch

  • 0Cancer Center, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University Dongguan, Guangdong, The People's Republic of China.
American Journal of Cancer Research +

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July 16, 2025

|

July 16, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Epithelial Splicing Regulatory Protein 1 (ESRP1) is elevated in breast cancer, impacting patient outcomes. Its role varies by estrogen receptor status, suggesting subtype-specific therapeutic strategies.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Epithelial Splicing Regulatory Protein 1 (ESRP1) is an epithelial splicing regulator.
  • ESRP1's role in breast cancer invasiveness and metastasis is known, but its prognostic value and interaction with estrogen receptors (ER) require further elucidation.

Purpose Of The Study

  • To investigate the prognostic significance of ESRP1 in breast cancer.
  • To explore the functional interplay between ESRP1 and estrogen receptors (ER) in breast cancer progression.

Main Methods

  • Analysis of ESRP1 expression in breast cancer tissues.
  • In vitro studies using ER-positive and ER-negative breast cancer cell lines.
  • Manipulation of ESRP1 expression and ER signaling pathways.

Main Results

  • ESRP1 is upregulated in breast cancer and associated with adverse outcomes, especially in ER-positive cases.
  • ESRP1 knockdown inhibits proliferation in ER-positive cells but affects invasion/migration in ER-negative cells.
  • In ER-positive cells, ESRP1 inhibition promotes EMT and enhances invasion, indicating a complex regulatory role dependent on ER status.

Conclusions

  • ESRP1 is a potential prognostic marker for breast cancer, with its significance being subtype-specific.
  • ESRP1's therapeutic targeting requires careful consideration of the ER background due to its context-dependent functions.

Keywords:

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