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Related Concept Videos

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Papillary Dermis01:11

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Prodrugs are a class of pharmaceutical compounds that undergo a biotransformation process within the body to be converted into a pharmacologically active drug. Prodrugs are designed to improve the therapeutic properties of the parent drug, such as enhancing bioavailability, increasing stability, or reducing toxicity. The concept of prodrugs revolves around modifying the chemical structure of the original drug to make it more effective or convenient for administration.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Expanding Prospects for Dermal Health with Bioactive Phytochemicals.

Ishu Garg1, Neelam Singh2, Neha3

  • 1School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University Balawala, Dehradun, Uttarakhand, 248161, India.

Recent Advances in Inflammation & Allergy Drug Discovery
|July 16, 2025
PubMed
Summary
This summary is machine-generated.

Phytochemicals, plant-derived compounds, show promise in treating skin diseases by reducing inflammation and protecting against damage. Further research is exploring their therapeutic potential for various dermatological conditions.

Keywords:
Phytochemicalschronic inflammationdermal illnessextraction.plantsskin regeneration

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Area of Science:

  • Dermatology and Plant-based Therapeutics
  • Skin Health and Disease Mechanisms

Background:

  • Skin health is vital for quality of life, with chronic inflammation underlying many dermatological conditions.
  • Immune-mediated reactions, if unregulated, can cause cellular damage and lead to skin diseases like acne, eczema, psoriasis, and skin cancer.
  • Phytochemicals, plant-produced compounds with biological activities, are explored for therapeutic applications.

Purpose of the Study:

  • To review current research on the effects of phytochemicals on dermal illnesses.
  • To elucidate the underlying mechanisms of action for phytochemicals in treating skin conditions.

Main Methods:

  • Literature review of studies on phytochemicals and skin health.
  • Analysis of research investigating phytochemicals' molecular targets and biological activities.
  • Summarization of findings on phytochemicals' impact on inflammatory pathways and cellular protection.

Main Results:

  • Phytochemicals demonstrate protective effects against skin damage by quenching free radicals.
  • They suppress nuclear factor-κB (NF-κB), a key regulator of inflammation.
  • Phytochemicals offer a safe topical delivery system for skin improvement and regenerative treatment.

Conclusions:

  • Phytochemicals possess significant therapeutic potential for managing various dermatological diseases.
  • Their anti-inflammatory and antioxidant properties make them valuable agents for skin health.
  • Continued research into phytochemical mechanisms will advance their clinical application in dermatology.