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Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
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Common Hematologic Emergencies-Acute Promyelocytic Leukemia and Microangiopathic Hemolytic Anemias-A Pivotal Role of

Ganna Shestakova1,2, Nicolas Ulrich Edgar3, Anton V Rets1,2

  • 1University of Utah, Department of Pathology, Salt Lake City, Utah, USA.

International Journal of Laboratory Hematology
|July 16, 2025
PubMed

Hematologic emergencies are urgent health conditions which result in significant mortality and morbidity unless timely therapeutic measures are taken. Therapeutic success depends on their timely and accurate recognition by hematology laboratory services. This review highlights the laboratory's role in identifying conditions associated with increased schistocytes (thrombotic microangiopathies) and acute promyelocytic leukemia. Their detection based on the routine laboratory and morphology methods should trigger appropriate additional laboratory workup including molecular tests, flow cytometry, etc. Hematology laboratory professionals should be skilled to recognize these emergencies and recommend additional workup, playing a critical role in the timely diagnosis and management of life-threatening conditions.

Keywords:
APLacute promyelocytic leukemiahematologic emergencyschistocytesthrombotic microangiopathic anemia

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