Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral colon-targeted micro-nano formulation engineered in microfluid for synergistic therapy of inflammatory bowel disease.

Biomaterials·2026
Same author

Reconstruction of the Achilles tendon using LARS artificial ligament in bilateral xanthoma: a case report and literature review.

BMC surgery·2026
Same author

Affinity-Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics.

Advanced healthcare materials·2026
Same author

Overcoming high-temperature performance limitations: Multidimensional design and innovation of thin-film thermocouples.

iScience·2026
Same author

The effect of active warming and conventional body temperature management on perioperative blood loss and coagulation function in patients undergoing scoliosis correction: a multicenter randomized controlled trial.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

A pathogen lncRNA secreted into rice sequesters a host miRNA for virulence.

Nature·2026

Related Experiment Video

Updated: Sep 15, 2025

Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles
12:47

Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles

Published on: October 4, 2012

18.0K

Clean and Open Yo-Yo-Shaped Nanoparticle with Large and Sensitive Hot Space Enhanced Raman Spectroscopy in

Guoliang Zhou1,2, Jiazheng Wang3, Shirui Weng1,4

  • 1Institute of Nuclear Energy Safety Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.

Analytical Chemistry
|July 16, 2025
PubMed
Summary

Researchers developed yo-yo-shaped nanoparticles for Surface-Enhanced Raman Spectroscopy (SERS). This "hot space" design efficiently delivers analytes, enhancing sensitivity and stability for drug detection and clinical diagnosis.

More Related Videos

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
13:15

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

11.1K
Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

22.5K

Related Experiment Videos

Last Updated: Sep 15, 2025

Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles
12:47

Tangential Flow Ultrafiltration: A “Green” Method for the Size Selection and Concentration of Colloidal Silver Nanoparticles

Published on: October 4, 2012

18.0K
Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
13:15

Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy

Published on: July 18, 2014

11.1K
Optical Trapping of Nanoparticles
13:39

Optical Trapping of Nanoparticles

Published on: January 15, 2013

22.5K

Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Materials Science

Background:

  • Surface-Enhanced Raman Spectroscopy (SERS) traditionally focuses on increasing hot spot density.
  • Simply increasing hot spots or reducing spacing does not guarantee improved SERS performance.
  • Efficient analyte delivery and uniform field intensity are crucial for high-sensitivity SERS.

Purpose of the Study:

  • To develop a facile strategy for fabricating novel nanostructures for advanced SERS applications.
  • To create open nanostructures that facilitate analyte entry into homogeneous hot spots.
  • To enhance SERS sensitivity and stability through optimized nanostructure design.

Main Methods:

  • Fabrication of yo-yo-shaped nanoparticles using a surfactant removal process.
  • Utilizing solvent washing and chloride ion substitution in dilute colloidal solutions.
  • Characterization of nanoparticle morphology and hot spot characteristics.

Main Results:

  • Formation of clean, open yo-yo-shaped nanoparticles with homogeneous "hot space" zones.
  • Demonstrated high uniformity in nanoparticle colloid, with <10% RSD for 5-fluorouracil (5-FU) detection.
  • Achieved a 101.25% recovery rate for 5-FU in real human serum samples.

Conclusions:

  • Yo-yo-shaped nanoparticles provide a "hot space" for efficient analyte delivery, enhancing SERS sensitivity and stability.
  • The developed nanoparticle colloid strategy exhibits excellent uniformity and reliability.
  • This approach offers a valuable platform for SERS quantitative detection in fluid sensing and clinical diagnosis.