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Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
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Moderate-intensity exercise training uniquely modulates circulating lipid species beyond classical lipid levels in
Yu Zhang1, Zhengzheng Zhang1, Borja Martinez-Tellez2
1Metabolomics and Analytics Centre, Leiden Academic Centre for Drug Research (LACDR), Leiden University, the Netherlands.
Ebiomedicine
|July 16, 2025
Summary
Moderate-intensity exercise selectively modifies specific lipid subtypes, enhancing health benefits. This exercise approach impacts glycerophospholipids and triacylglycerols differently in men and women, unlike vigorous-intensity exercise.
Area of Science:
- Exercise physiology and lipid metabolism research.
- Investigating the impact of exercise intensity on plasma lipid profiles.
Background:
- Regular physical exercise offers significant health benefits.
- These benefits may be mediated by exercise intensity-dependent modulation of lipid metabolism.
Purpose of the Study:
- To investigate the effects of moderate- versus vigorous-intensity exercise on plasma lipid profiles.
- To identify sex-specific responses to different exercise intensities.
Main Methods:
- A 24-week supervised concurrent exercise intervention was conducted.
- 101 young, sedentary adults were randomized to moderate or vigorous intensity exercise.
- Plasma lipid species (794) across 18 subclasses were profiled.
Main Results:
- Moderate-intensity exercise, but not vigorous-intensity, increased glycerophospholipids and triacylglycerol species.
- Men showed increased glycerophospholipids and lysophospholipids; women showed increased triacylglycerols with moderate exercise.
- Increases in glycerophospholipids correlated with cardiorespiratory fitness (VO2peak).
Conclusions:
- Exercise impacts health by selectively altering specific lipid subtypes.
- These alterations are dependent on exercise intensity and sex.
- Traditional lipid markers remained unchanged, highlighting the importance of specific lipid profiling.
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