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Updated: Sep 15, 2025
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Sinonasal intestinal-type adenocarcinoma: Multi-institutional retrospective analysis based on 440 patients with
Iacopo Dallan1, Giacomo Fiacchini2, Domenico Tricò3
1Skull Base and Rhino-orbital Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Azienda Ospedaliero-Universitaria Pisana (AOUP), Pisa, Italy.
Background:
Sinonasal intestinal-type adenocarcinoma (ITAC) is the most common nasoethmoidal cancer in European countries. Subtypes and other prognostic factors/parameters are known to be associated with prognosis.
Methods:
We performed a retrospective analysis of prognostic factors associated with overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) in patients affected by histologically-proven sinonasal ITAC, managed with an endoscopic surgery-centered protocol in 6 European centers. A prognostic study with multivariable analysis was performed.
Results:
Mean follow up was 74 months. 5-year CSS was 81.7 %, varying substantially according to the histologic subtype, ranging from 94.8 % for well differentiated tubulo-papillary subtype to 32.7 % for signet-ring cell ITAC. Whole group 5-year recurrence rate was 30.8 %, ranging from 18.7 % for well differentiated tubulo-papillary subtype to 73.8 % for signet-ring cell ITAC.
Conclusion:
Considering ITAC as a single entity is no longer advisable, as different subtypes carry remarkably different prognosis. Until novel, standardized biomarkers will be available, ITAC management needs to be customized upon several factors, with histopathology-based subtyping being exceedingly relevant.
