Interventional Radiological Management for Budd-Chiari Syndrome: A 10-Year Retrospective, Multicenter Survey on 997...

Area of Science:

• Interventional Radiology
• Hepatology
• Vascular Medicine

Background:

• Budd-Chiari syndrome (BCS) is a rare liver disease caused by hepatic venous outflow obstruction.
• Large-scale studies on interventional radiological treatments for BCS are limited.
• Understanding long-term outcomes is crucial for patient management.

Purpose of the Study:

• To evaluate the long-term outcomes of interventional radiological treatments for BCS in Chinese patients.
• To assess the effectiveness of percutaneous angioplasty (PTA) with or without stenting and transjugular intrahepatic portosystemic shunt (TIPS).
• To analyze survival rates and factors influencing outcomes in a large BCS cohort.

Main Methods:

• Retrospective analysis of 997 consecutive BCS patients from 6 Chinese tertiary centers (January 2010 - May 2019).
• Inclusion criteria focused on patients diagnosed with BCS and treated with interventional radiological procedures.
• Assessment of treatment modalities (PTA, stenting, TIPS) and clinical outcomes, including survival rates.

Main Results:

• Inferior vena cava obstruction was the most common type (68.1%).
• 83.7% of patients underwent successful recanalization via PTA (alone or with stenting).
• The 5-year overall survival rate was 90.2%, with deaths primarily due to liver failure. Survival rates varied significantly based on treatment received (e.g., intervention-free vs. overall).

Conclusions:

• Interventional radiological treatments, especially recanalization techniques, achieve favorable long-term outcomes in Chinese BCS patients.
• PTA with or without stenting is a primary effective treatment modality.
• Further research may explore optimizing treatment strategies for different BCS subtypes.