The multifaceted role of exosomes in ferroptosis-associated diseases and its potential applications

Ferroptosis, a newly identified type of regulated cell death characterized by iron-dependent lipid peroxidation, is crucial in multiple pathological conditions. While it shows potential as a therapeutic target for various diseases, numerous mysteries surrounding its mechanisms persist, underscoring the need for further research into therapy and prevention strategies. Exosomes, key players in intercellular communication, are increasingly recognized for their therapeutic potential. Emerging evidence indicates their involvement in regulating ferroptosis, offering insights into the application of ferroptosis-associated diseases. This review compiles and synthesizes mechanisms underlying the interaction between exosomes and ferroptosis, along with their potential applications in disease diagnosis, treatment, and prognosis, drawing on bibliographies from prior research findings. We anticipate this review could provide novel perspectives on exosome-mediated intervention in ferroptosis-associated diseases.