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Unlocking new frontiers in kidney diseases: targeting endothelial dysfunction with emerging biomarkers and therapies

Rohan Bhadange1, Anil Bhanudas Gaikwad1

  • 1Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.

Drug Discovery Today
|July 16, 2025
PubMed

Insights

This review explores novel biomarkers for kidney diseases, focusing on their role in endothelial dysfunction. Identifying these markers may lead to new therapeutic strategies for managing kidney conditions.

Area of Science:

  • Nephrology
  • Vascular Biology
  • Biomarker Discovery

Background:

  • Kidney diseases pose a significant global health challenge, characterized by complex pathological mechanisms.
  • Endothelial dysfunction, influenced by the endothelin system, is a critical factor in kidney disease progression.
  • Current diagnostic and therapeutic options for kidney disease-related endothelial dysfunction are limited.

Purpose of the Study:

  • To review emerging biomarkers associated with kidney diseases and endothelial dysfunction.
  • To highlight the diagnostic and therapeutic potential of these novel markers.
  • To explore advancements in preclinical and clinical kidney disease management.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of emerging biomarkers including endoglin, periostin, fetuin-A, endocan, and cytokeratin (CK)-18.
  • Evaluation of the role of the endothelin system in kidney pathophysiology.

Main Results:

  • Several novel biomarkers show promise in diagnosing and potentially treating kidney diseases.
  • These biomarkers are linked to key pathological processes like inflammation, oxidative stress, and fibrosis.
  • Endothelial dysfunction biomarkers offer new avenues for therapeutic intervention.

Conclusions:

  • Emerging biomarkers like endoglin and periostin hold significant potential for kidney disease management.
  • Further research into these markers could lead to improved diagnostic tools and novel therapeutic strategies.
  • Targeting endothelial dysfunction is crucial for advancing kidney disease treatment.
Keywords:
E-selectinbiomarkersendoglinendothelin dysfunctionkidney diseasesperiostintherapeutic targets

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