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Related Concept Videos

Dialysis01:15

Dialysis

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Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...
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Three-Dimensionally Printed Microfluidic Cross-flow System for Ultrafiltration/Nanofiltration Membrane Performance Testing
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Flash: Dual-gradient filtering membranes enable ultra-fast plasma separation.

Xianchang Wu1, Hui Niu2, Tonghuan Zhan1

  • 1School of Mechanical Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.

Analytica Chimica Acta
|July 16, 2025
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Summary

A novel dual-gradient plasma separation membrane (DG-PSM) rapidly isolates pure plasma from whole blood. This advancement significantly enhances point-of-care diagnostic capabilities, especially in remote settings.

Keywords:
Dual-gradientMicroscale blood separationPlasma separation membranesRBC agglutinationWetting

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Area of Science:

  • Biomaterials Science
  • Analytical Chemistry
  • Point-of-Care Diagnostics

Background:

  • Whole blood contains numerous components that interfere with biomarker detection in plasma.
  • Current plasma separation methods are often slow and inefficient for point-of-care (POC) applications.
  • Rapid, high-purity plasma separation is critical for effective POC testing.

Purpose of the Study:

  • To develop an advanced plasma separation membrane for rapid and high-purity plasma extraction.
  • To overcome the limitations of existing plasma separation techniques in POC settings.
  • To enable efficient biomarker detection from small blood volumes.

Main Methods:

  • Fabrication of dual-gradient plasma separation membranes (DG-PSMs) with structural and wetting gradients.
  • Utilizing antibody pre-treatment for red blood cell agglutination.
  • Employing wetting gradient force for rapid plasma transport.
  • Integrating DG-PSMs with microfluidic paper-based analytical devices (μPADs) for glucose detection.

Main Results:

  • DG-PSMs achieved >99.99% plasma purity from 15 μL whole blood in just 15 seconds.
  • Ultra-high protein recovery rate of ~98.88% was obtained due to rapid separation.
  • The DG-PSM demonstrated comparable performance to centrifugation in preventing red blood cell hemolysis.
  • Integrated system enabled rapid blood glucose detection (~20 seconds).

Conclusions:

  • DG-PSMs offer a highly efficient solution for rapid, high-purity plasma separation.
  • This technology facilitates lab-on-a-chip integration for diagnostics.
  • DG-PSMs have significant potential for improving healthcare in remote and underserved areas.