Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Physiology01:30

Liver Physiology

1.3K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
1.3K
Liver Regeneration01:24

Liver Regeneration

3.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.4K
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

146
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
146
Hepatic Portal System01:21

Hepatic Portal System

2.3K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
2.3K
Liver Histology01:27

Liver Histology

1.6K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
1.6K
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to Identify and Treat MetALD.

Gastroenterology & hepatology·2026
Same author

Increased Risk for Liver Disease in Patients With Chronic Hepatitis B Virus Infection and Low-Level Viraemia.

Alimentary pharmacology & therapeutics·2026
Same author

Evaluation of Abnormal Liver Biochemical Test Results.

Gastroenterology·2026
Same author

A systematic review of post-liver transplantation treatment and outcomes for late T-cell mediated, chronic ductopenic, and antibody-mediated rejection.

Hepatology communications·2026
Same author

International Expert Delphi Consensus on Endoscopic Ultrasound-guided Portosystemic Pressure Gradient: Best Practices and Future Directions.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2025
Same author

Multi-Society Expert Panel Consensus Guidance Regarding Clinical Assessment and Clinical Trial Endpoints in Adults With Alpha-1 Antitrypsin Deficiency-Associated Liver Disease.

Gastroenterology·2025

Related Experiment Video

Updated: Sep 15, 2025

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

10.4K

The Liver in Sepsis.

Adily N Elmi1, Paul Y Kwo2

  • 1Department of Internal Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Room 3575 Lakeside, Cleveland, OH 44106, USA; Division of Gastroenterology and Hepatology, Stanford University, Palo Alto, CA, USA.

Clinics in Liver Disease
|July 16, 2025
PubMed
Summary

Sepsis severely impacts the liver, affecting metabolism and immune responses. This review details sepsis-induced liver dysfunction, its clinical findings, and therapeutic strategies, including liver transplantation.

Keywords:
ACLFAcute-on chronic liver failureCirrhosisLiver failureLiver transplantationSepsisSeptic shock

More Related Videos

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

19.6K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.2K

Related Experiment Videos

Last Updated: Sep 15, 2025

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver
07:06

Two-photon Intravital Imaging of Leukocytes During the Immune Response in Lipopolysaccharide-treated Mouse Liver

Published on: February 6, 2018

10.4K
Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies
07:34

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

Published on: April 11, 2012

19.6K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.2K

Area of Science:

  • Hepatology
  • Immunology
  • Critical Care Medicine

Background:

  • The liver is crucial for systemic responses to sepsis, regulating metabolism, immunity, and coagulation.
  • Sepsis leads to multi-organ dysfunction, with hepatic dysfunction significantly worsening disease severity.
  • Understanding liver's role in sepsis is vital for patient outcomes.

Purpose of the Study:

  • To review the impact of inflammatory, hemodynamic, and metabolic changes in sepsis on liver function.
  • To outline the clinical and laboratory manifestations of sepsis-induced liver dysfunction.
  • To discuss current and emerging treatments for sepsis-related liver injury and liver transplantation.

Main Methods:

  • Literature review focusing on sepsis pathophysiology and liver involvement.
  • Analysis of inflammatory, hemodynamic, and metabolic alterations during sepsis.
  • Synthesis of clinical and laboratory findings related to liver dysfunction in sepsis.

Main Results:

  • Sepsis triggers significant inflammatory, hemodynamic, and metabolic disturbances affecting the liver.
  • Hepatic dysfunction is a common and severe complication of sepsis.
  • Clinical presentation includes specific laboratory abnormalities indicative of liver injury.

Conclusions:

  • Sepsis profoundly affects liver function through multiple pathways.
  • Early recognition and management of sepsis-induced liver dysfunction are critical.
  • Emerging therapies and liver transplantation are important considerations for severe cases.