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Updated: Sep 15, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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FLG249 Exhibits FXR Antagonist Activity by Inducing Dissociation of Both Corepressors and Coactivators from FXR

Yusuke Iguchi1, Yukiko Yamashita1, Keigo Gohda2

  • 1Faculty of Pharmaceutical Sciences, Hiroshima International University, Kure, Hiroshima 737-0112, Japan.

Biological & Pharmaceutical Bulletin
|July 16, 2025
PubMed

Keywords:
bile aciddrug developmentfarnesoid X receptorlipid metabolismnuclear receptorprotein–protein interaction

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