Anatomical organization of primary visual cortex (area 17) in the ferret

The present report describes the intrinsic and extrinsic cortical connectivity of striate cortex (area 17) in the ferret. Injections of horseradish peroxidase demonstrate periodic intrinsic connections over an extent of 2.5-3.0 mm, mainly in the supragranular layers but also occurring secondarily in layer 5. These connections have a stripelike configuration, with a center-to-center spacing of 0.5-0.7 mm. Their laminar distribution and stripelike configuration resemble the pattern in the cat (Gilbert and Wiesel, '83), another member of the carnivore family, but not that in monkeys. In both macaque and squirrel monkeys, these connections have a bilaminar distribution in layers 2-3 and 4B, and a more complicated latticelike geometry (Rockland and Lund, '83). Their interperiod spacing, of about 0.5 mm, however, is relatively constant across species. Extrinsic connections in the ferret link striate cortex with territories probably homologous to feline areas 18 and 19, and to the suprasylvian region. Callosal connections extend on the lateral surface about 1.5 mm into area 17 and 4.0 mm into area 18 beyond their common border. There are homotopical connections between striate cortices and heterotopical connections from at least areas 18 and 19 to contralateral area 17. In addition to gray matter connections, intracortical injections also result in labeled interstitial neurons in the subgriseal white matter. These occur both subjacent to an injection site in area 17, and below labeled foci in area 18 projecting back to area 17, as if interstitial neurons shared the connectivity of overlying layer 6.