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Updated: Sep 15, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Copper-Catalyzed Diastereoselective Borylative α-(N-Aryl)aminoalkylation of Vinyl Arenes with Nitrones
Jingyu Li1, Long Chen1, Ziqi Dang1
1School of Environmental and Chemical Engineering, Jiangsu Ocean University, Lianyungang, Jiangsu 222005, China.
Abstract:
A copper-catalyzed three-component coupling of vinyl arenes, bis(pinacolato)diboron, and nitrones has been developed, which offers access to a diverse range of γ-(N-aryl)amino boronates via reductive workup, exhibiting good-to-excellent diastereoselectivities. This new protocol, which can be performed at a gram scale, utilizes nitrones as simple precursors and provides γ-amino boronates having versatile utilities in downstream applications. Additionally, oxidative pathway control allows the selective generation of 3-substituted α,β-unsaturated imines, expanding the synthetic utility of this catalytic system.
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