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Precision-Engineered Nanononamers with Open Internal Hotspots for Single-Particle Surface-Enhanced Raman Scattering.

Yu Liu¹, Wei Zhang¹, Siyan Hu¹

¹State Key Laboratory of Flexible Electronics (LoFE) & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China.

ACS Applied Materials & Interfaces

|July 16, 2025

Summary

Researchers developed a simple method to create gold-silver nanononamers for enhanced electromagnetic near-field concentration. These nanostructures enable highly sensitive, label-free surface-enhanced Raman scattering (SERS) detection.

Keywords:

hotspot intraparticle nanogap localized surface plasmon resonance nanoframe plasmonic nanostructure

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Area of Science:

Nanotechnology
Materials Science
Spectroscopy

Background:

Plasmonic nanostructures with open nanogaps concentrate electromagnetic near-fields, crucial for label-free surface-enhanced Raman scattering (SERS) detection.
Precise engineering of these nanostructures for optimized near-field focusing is a significant challenge.

Purpose of the Study:

To present a facile synthetic strategy for fabricating frame-like gold-silver nanononamers (AuAg NNs).
To enable tunable internal hotspots for single-particle SERS applications.

Main Methods:

Controlled overgrowth of silver (Ag) layers on gold (Au) nanoparticles.
Galvanic replacement reaction to form interconnected AuAg nanosphere octamers encapsulating a central Au core.
Tuning of core Au nanoparticle shape and Ag layer thickness to adjust structural parameters and intragap sizes.

Main Results:

Fabrication of frame-like AuAg NNs with tunable internal hotspots.
Optimized AuAg NNs demonstrated intense near-field focusing at the nanogaps.
Achieved high single-particle SERS activity, indicating ultrasensitive detection capabilities.

Conclusions:

The developed synthetic strategy provides a simple and general approach for fabricating AuAg NNs with tunable hotspots.
These nanostructures show significant potential for ultrasensitive SERS applications.
Precise control over structural parameters enables optimized near-field focusing for enhanced detection.