Serum melatonin as a potential biomarker for COVID-19 severity
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View abstract on PubMed
Summary
This summary is machine-generated.Lower serum melatonin levels correlate with increased COVID-19 severity. This study suggests melatonin may be a useful biomarker for predicting disease progression in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Area Of Science
- Immunology
- Endocrinology
- Infectious Diseases
Background
- The global impact of COVID-19 necessitates reliable biomarkers for predicting disease severity.
- Melatonin, an immunomodulatory and antioxidant hormone, has potential roles in viral infection inflammation.
- The association between serum melatonin and COVID-19 severity requires further investigation.
Purpose Of The Study
- To assess the correlation between serum melatonin concentration and COVID-19 severity.
- To identify serum melatonin as a potential prognostic biomarker for COVID-19.
Main Methods
- A cohort study of COVID-19 patients (June 2020 - July 2022).
- Measurement and analysis of serum melatonin levels in relation to disease severity and oxygen requirements.
- Comparison of serum melatonin levels between survivors and non-survivors.
Main Results
- Patients not requiring oxygen had significantly higher serum melatonin (45.09 pg/mL) than those needing intensive oxygen (32.17 pg/mL) (p < 0.0001).
- Median serum melatonin was higher in survivors (41.57 pg/mL) versus non-survivors (24.79 pg/mL) (p = 0.0005).
- Lower serum melatonin was observed in non-survivors with respiratory distress and stress (p = 0.0022).
Conclusions
- Serum melatonin concentration at admission was significantly lower in patients with critical or fatal COVID-19.
- Serum melatonin levels may serve as a potential biomarker for predicting COVID-19 severity.
- Further research into melatonin's role in COVID-19 pathogenesis is warranted.
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