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Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

Andrew McPherson1,2, Ignacio Vázquez-García3,4,5,6,7, Matthew A Myers3,4

  • 1Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. mcphera1@mskcc.org.

Nature
|July 16, 2025
PubMed
Summary

Whole-genome doubling (WGD) drives cancer evolution and immune evasion in ovarian tumors. This ongoing process impacts tumor diversity, chromosomal instability, and immune suppression, revealing new therapeutic targets.

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