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Cross-reactivity

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: Jul 7, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Cross allergenicity among grasses determined by tissue threshold changes.

D C Leavengood, R L Renard, B G Martin

The Journal of Allergy and Clinical Immunology

|December 1, 1985

Summary

This summary is machine-generated.

Grass pollen immunotherapy using timothy and Bermuda grass extracts significantly reduced allergic sensitivity to all 10 tested grass pollens. This suggests timothy and Bermuda grass immunotherapy may be sufficient for most individuals with grass pollen allergies.

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Area of Science:

Allergy and Immunology
Immunotherapy Research
Clinical Trials

Background:

Grass pollen allergy affects a significant portion of the population.
Current immunotherapy options often involve complex allergen mixtures.
Identifying simplified effective immunotherapy regimens is crucial for patient management.

Purpose of the Study:

To evaluate the efficacy of immunotherapy with timothy and Bermuda grass extracts.
To determine if this immunotherapy reduces sensitivity to a broader range of grass pollens.
To assess the sufficiency of timothy and Bermuda grass immunotherapy for general grass pollen allergy.

Main Methods:

Twenty-seven volunteers with grass pollen allergy underwent titrated skin testing.
Seventeen subjects received immunotherapy with timothy and Bermuda grass extract.
A control group of ten subjects received no immunotherapy.
Skin testing was repeated after 12 months of immunotherapy.

Main Results:

The treated group showed a significant decrease in skin test reactions to all 10 grass pollens compared to controls (p < 0.01).
The reduction in skin test sensitivity was consistent across all 10 grass species studied.
Nine treated subjects and eight control subjects completed the study.

Conclusions:

Immunotherapy with timothy and Bermuda grass extracts effectively reduces clinical sensitivity to multiple grass pollens.
Treatment with timothy and Bermuda grass alone appears sufficient for managing sensitivity in most grass-allergic individuals.
This simplified immunotherapy approach may offer a more accessible treatment option.