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Related Experiment Video

Updated: Jun 25, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Population differences in cutaneous methacholine reactivity and circulating IgE concentrations.

C E Buckley, J W Larrick, J E Kaplan

The Journal of Allergy and Clinical Immunology

|December 1, 1985

Summary

Allergic symptoms are rare in Amazonian Indians despite high IgE levels, unlike North Carolina subjects. Parasitism influences immune responses, showing an inverse relationship between IgE and skin reactivity.

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Area of Science:

Immunology
Environmental Health
Anthropology

Background:

Allergic diseases vary significantly across different global populations and environments.
Parasitic infections are known to modulate the human immune system, potentially affecting allergic responses.

Purpose of the Study:

To investigate the prevalence of allergic symptoms, serum IgE levels, and cutaneous reactivity to allergens and methacholine in three distinct populations.
To explore the influence of altitude, environment, and parasitic load on allergic sensitization and immune responses.

Main Methods:

Cross-cultural study comparing Waorani Indians (Amazon), Tibetans (Himalayas), and North Carolina (USA) residents.
Assessed allergic/vasomotor symptoms, serum IgE concentrations, allergen skin tests, and methacholine challenge.
Quantified parasitic infection levels in each group.

Main Results:

Waorani Indians exhibited very low rates of allergic symptoms and positive skin tests, contrasting sharply with North Carolina subjects.
Serum IgE concentrations were markedly higher in Waorani and Tibetans compared to North Carolina subjects.
A significant inverse correlation was found between serum IgE levels and methacholine-induced cutaneous flare response across populations.

Conclusions:

High altitude and parasitic infections may suppress typical allergic responses, despite elevated IgE levels.
Environmental factors and parasitic load play a crucial role in shaping immune system's allergic phenotype.
The study highlights the complex interplay between environment, infection, and allergic disease prevalence.