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Teratoid Hepatoblastoma: Clinicopathologic Features and Outcomes
Brian T Hickner1, Andres F Espinoza1, Soo Jin Cho2
1Division of Pediatric Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Surgical Oncology Program and Liver Tumor Program, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.
Pediatric Blood & Cancer
|July 17, 2025
Summary
Teratoid hepatoblastoma (HB) is a rare pediatric liver cancer subtype. This study found teratoid HB occurs in younger males, is chemoresistant, and presents with more metastases, yet survival is comparable to non-teratoid HB.
Area of Science:
- Pediatric oncology
- Hepatoblastoma research
- Cancer subtypes
Background:
- Teratoid hepatoblastoma (HB) is a rare histologic subtype of pediatric liver cancer.
- Limited understanding of teratoid HB clinicopathologic features and outcomes exists.
Purpose of the Study:
- To compare clinicopathologic features and outcomes of teratoid HB versus non-teratoid HB in children.
- To provide insights into the characteristics and treatment of this rare cancer subtype.
Main Methods:
- Retrospective chart review of 20 children with teratoid HB and 129 with non-teratoid HB (2004-2022).
- Analysis of patient demographics, treatment response, metastasis, relapse, and survival rates.
Main Results:
- Teratoid HB more frequent in males and children <5 years old.
- Teratoid HB showed lower chemoresponsiveness and higher rates of metastases at presentation.
- Survival rates were comparable between teratoid and non-teratoid HB groups.
Conclusions:
- Teratoid HB is associated with younger age and chemoresistance.
- Despite increased metastatic burden at diagnosis, teratoid HB outcomes are similar to non-teratoid HB.
- This study represents a significant comparison of teratoid and non-teratoid HB in pediatric patients.
