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Related Concept Videos

Maximum Size of Aggregate01:12

Maximum Size of Aggregate

238
The maximum size of aggregate is defined as the aperture of the sieve retaining 15 percent or more of the particles present in the aggregate sample. The aggregate's maximum size impacts the concrete's water requirement, workability, and strength. Larger aggregates reduce the surface area needing cement paste coverage, which can lower water needs, thereby allowing a decrease in the water-to-cement ratio when the desired workability and richness of the mix are to be maintained, which can...
238
Aggregates Classification01:29

Aggregates Classification

387
Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
387
Unsoundness of Aggregate due to Volume Change01:26

Unsoundness of Aggregate due to Volume Change

181
Unsoundness in aggregates due to volume changes is primarily caused by the physical alterations aggregates undergo, such as freezing and thawing, thermal changes, and wetting and drying. Unsound aggregates, when subjected to these changes, result in volume change upon disintegration. This, in turn, contributes to the deterioration of concrete, including scaling, pop-outs, and cracking. Particular types of aggregates, such as porous flints, cherts, and those containing clay minerals, are...
181

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Related Experiment Video

Updated: Sep 15, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
09:22

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

Published on: January 2, 2015

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Tau aggregation.

Indalo Domene-Serrano1,2, Ismael Santa-María2, Felix Hernandez2

  • 1Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.

Histology and Histopathology
|July 17, 2025
PubMed
Summary
This summary is machine-generated.

Microtubule-associated protein tau (MAPT) aggregation drives tauopathies. Different tau isoforms with three or four binding repeats form distinct aggregates, offering therapeutic targets for neurodegenerative diseases.

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Related Experiment Videos

Last Updated: Sep 15, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Biochemistry

Background:

  • Microtubule-associated protein tau (MAPT) exists in neuronal isoforms differing by microtubule-binding repeats.
  • These repeats influence tau's interaction with microtubules and its pathological self-aggregation.
  • Tau aggregates are hallmarks of tauopathies, a class of neurodegenerative disorders.

Purpose of the Study:

  • To investigate the mechanisms of tau self-aggregation.
  • To identify molecular and cellular factors driving tau aggregation.
  • To analyze the structural characteristics of tau aggregates.

Main Methods:

  • Examining tau isoform structures.
  • Investigating factors influencing tau aggregation.
  • Analyzing the morphology of tau aggregates.

Main Results:

  • Distinct aggregate morphologies arise from tau isoforms with three versus four microtubule-binding repeats.
  • These distinct morphologies correlate with specific tauopathies.
  • Understanding these differences is key to disease classification.

Conclusions:

  • Tau self-aggregation mechanisms and driving factors are complex.
  • Isoform-specific aggregate structures are critical pathological features.
  • Targeting tau aggregate formation or clearance presents therapeutic avenues for tauopathies.