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Related Concept Videos

The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Molecular characterisation of progressive pulmonary sarcoidosis: protocol for a longitudinal multi-centre study to develop peripheral blood circulating biomarkers for predicting pulmonary sarcoidosis progression.

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Related Experiment Video

Updated: Sep 15, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
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Deciphering sarcoidosis immunopathogenesis through systems biology.

Aiham H Jbeli1, Elliott D Crouser2, Maneesh Bhargava2

  • 1Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

Current Opinion in Pulmonary Medicine
|July 17, 2025
PubMed
Summary

Recent multiomics research reveals key biological pathways and biomarkers for sarcoidosis, a complex inflammatory disease. These findings offer new therapeutic targets to improve patient outcomes.

Keywords:
epigenomicsgenomicsprogressive phenotypesarcoidosistranscriptomics

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Area of Science:

  • Multiomics research in immunology and systems biology.
  • Investigating complex, multisystem diseases like sarcoidosis.

Background:

  • Sarcoidosis is a multisystem disease with variable outcomes, driven by genetic, environmental, and epigenetic factors.
  • Pathogenesis involves immune response to unknown triggers, leading to granuloma formation and potential organ dysfunction.

Purpose of the Study:

  • To synthesize recent multiomics research for a systems-level understanding of sarcoidosis.
  • To unravel the intricate biological networks underlying sarcoidosis pathogenesis and progression.

Main Methods:

  • Review of transcriptomics, epigenomics, and proteomics studies.
  • Analysis of multiomics data to identify biological networks and biomarkers.

Main Results:

  • Identification of potential biomarkers such as microRNAs, CD14, LBP, HBEGF, eNAMPT, and ANG-2.
  • Highlighting the PI3K/AKT pathway's role in immune activation.
  • Emergence of noninvasive methods like extracellular vesicle profiling.

Conclusions:

  • Recent multiomics findings illuminate key molecular pathways in sarcoidosis pathogenesis.
  • These discoveries offer opportunities for novel therapeutic targets.
  • Potential to transform clinical management and improve patient outcomes.