Prenatal diagnosis of balanced translocation from three families: Six case reports

Carriers of chromosomal balanced translocations are often physically healthy with no obvious developmental problems. However, potential chromosomal imbalance in their gametes can lead to implantation failure, miscarriage, or the birth of a child with a chromosomal abnormality.

We report six cases of chromosomal translocations involving three families, including the specific Robertson (Roche) translocation. Case 1: The karyotype of the proband was 46, XX, t(18;19)(q22;p12). Case 2: Interventional prenatal diagnosis at 18 weeks of gestation confirmed that the karyotype of the fetus was 46, XY, t(18;19)(q22;p12). Case 3: The karyotype of the proband was 46, XY, t(5;18)(p13;p11). Case 4: Interventional prenatal diagnosis at 14+6 weeks confirmed that the karyotype of the fetus was 46, XX, der(18)t(5;18)(p13;p11)pat. Case 5: The karyotype of the proband was 45, XY, der(14;22)(q10;q10). Case 6: Interventional prenatal diagnosis at 19+4 weeks confirmed that the karyotype of the fetus was 45, XX, rob(14;22)(q10;q10).

Carriers of chromosomal translocations have a high risk of adverse pregnancy outcomes, though they can still have normal offspring. This report on six cases of chromosomal translocations from three families could serve as a reference for future prenatal diagnosis of chromosomal translocations and decision-making on whether to continue the pregnancy.