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Inflammation in MASLD progression and cancer
Yeonsoo Kim1, Yunseo Park1, Hyunsoo Rho2
1College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan, Republic of Korea.
JHEP Reports : Innovation in Hepatology
|July 17, 2025
Summary
Inflammation drives the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) from fat accumulation to cancer. This review explores MASLD
Area of Science:
- Hepatology and Gastroenterology
- Immunology
- Molecular Biology
Background:
- Steatotic liver diseases encompass MASLD, ALD, and MetALD, progressing from steatosis to cirrhosis and cancer.
- MASLD and MetALD are major causes of chronic liver disease, driven by metabolic dysfunction and alcohol.
- Inflammation is key to steatosis progression, distinguishing it from steatohepatitis and hepatocellular carcinoma.
Purpose of the Study:
- To review current understanding of inflammatory mechanisms in MASLD pathogenesis.
- To identify molecular targets for potential pharmacological interventions in MASLD.
- To discuss inflammatory pathways in MetALD, highlighting similarities and differences with MASLD.
Main Methods:
- Literature review of inflammatory mechanisms in MASLD.
- Analysis of molecular targets for therapeutic strategies.
- Comparative review of inflammatory pathways in MASLD and MetALD.
Main Results:
- Inflammation is a critical driver of MASLD progression.
- Specific molecular pathways involved in MASLD pathogenesis are identified.
- Pathological similarities and distinctions between MASLD and MetALD inflammatory processes are outlined.
Conclusions:
- Understanding MASLD inflammation is crucial for developing targeted therapies.
- Pharmacological targeting of inflammatory pathways holds promise for MASLD treatment.
- Comparative analysis of MASLD and MetALD provides insights into shared and distinct disease mechanisms.
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