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Cryptogenic Fusobacterium liver abscesses in two healthy, young adult males

Cooper Alden Josephs1, Anna Bryce Tucker2, James Everhart3

  • 1Internal Medicine Resident, PGY-1, Memorial Health University Medical Center, Savannah, GA, USA.

Idcases
|July 17, 2025
PubMed
Abstract

Insights

Fusobacterium liver abscesses are rare in young men without Lemierre's syndrome. This study reports two such cases linked to binge drinking, suggesting a potential emerging public health concern requiring further investigation.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Microbiology

Background:

  • Lemierre's syndrome, a severe complication of oropharyngeal infections, is typically associated with Fusobacterium necrophorum.
  • Fusobacterium liver abscesses (PLAs) are uncommon, especially in the absence of Lemierre's syndrome.

Observation:

  • Two previously healthy young males presented with cryptogenic Fusobacterium liver abscesses.
  • Neither patient exhibited signs or symptoms of Lemierre's syndrome.
  • Both patients had a history of binge alcohol consumption.

Findings:

  • The cases highlight potential differences in disease presentation, bacterial species involved, and management strategies for Fusobacterium liver abscesses.
  • The absence of Lemierre's syndrome in these cases suggests alternative pathways for Fusobacterium dissemination to the liver.

Implications:

  • Further research is warranted to explore the association between Fusobacterium PLAs and alcohol consumption in young men.
  • Early source control for small liver abscesses may be crucial.
  • Public health officials should monitor this rare condition due to potential geographic and temporal clustering.
Keywords:
Alcohol use disorderBinge drinkingFusobacterium necroforumFusobacterium nucleatumPyogenic liver abscess

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