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Associations between feeding patterns and clinical outcomes of Hirschsprung's disease after surgery: propensity score

Wei Feng1, Xiao Xiang1, Xiaohong Die1

  • 1Department of General and Neonatal Surgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, China.

Frontiers in Nutrition
|July 17, 2025
PubMed

Insights

Breastfeeding is associated with better clinical outcomes in Hirschsprung

Area of Science:

  • Pediatric Surgery
  • Clinical Nutrition
  • Gastroenterology

Background:

  • Feeding patterns significantly impact physical development and health.
  • The effect of breastfeeding on clinical outcomes in Hirschsprung's disease (HSCR) is not well understood.
  • This study investigates feeding patterns' influence on HSCR postoperative outcomes.

Purpose of the Study:

  • To determine the impact of breastfeeding versus formula feeding on postoperative outcomes in patients with Hirschsprung's disease.
  • To identify potential risk factors for adverse outcomes in HSCR patients based on feeding type.

Main Methods:

  • Retrospective analysis of 296 HSCR patients undergoing laparoscopic-assisted pull-through surgery.
  • Propensity score matching (PSM) to compare breastfed and formula-fed groups.
  • Univariate/multivariate logistic regression to identify independent risk factors for postoperative complications.

Main Results:

  • Formula-fed patients exhibited higher rates of postoperative undernutrition (28.07% vs. 15.79%, p=0.023).
  • Formula feeding was linked to increased incidence of HAEC (47.37% vs. 22.81%, p=0.006) and bowel dysfunction (64.29% vs. 42.11%, p=0.018).
  • Formula feeding independently predicted higher risks of HAEC and bowel dysfunction post-surgery.

Conclusions:

  • Breastfeeding is associated with reduced rates of postoperative undernutrition, HAEC, and bowel dysfunction in HSCR patients.
  • Feeding patterns play a crucial role in the postoperative recovery of Hirschsprung's disease patients.
  • Promoting breastfeeding may improve clinical outcomes for children with HSCR.
Abstract

Keywords:
Hirschsprung’s diseaseclinical outcomefeeding patternlogistic regression analysispropensity score matching

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