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Collateral circulation significantly improves prognosis in cerebral infarction: a meta-analysis
Huafei Liu1, Nengyun Yao1, Haoyue Hu1
1The No. 1 Department of Neurology, First Affiliated Hospital of Shaoyang University Shaoyang 422001, Hunan, China.
Objective:
To systematically evaluate the association between collateral circulation and prognosis in patients with cerebral infarction through a meta-analysis.
Methods:
A comprehensive literature search was conducted across multiple databases to identify studies examining the relationship between collateral circulation and outcomes in cerebral infarction. Studies were screened based on predefined inclusion and exclusion criteria. Data were extracted and pooled using standard meta-analytic techniques.
Results:
A total of 41 studies encompassing 10,510 patients were included. Meta-analysis revealed that good collateral circulation was significantly associated with a favorable prognosis (pooled odds ratio [OR] = 1.67, 95% confidence interval [CI]: 1.35-2.07; P < 0.001). Subgroup analyses confirmed this association across different geographic regions and sample sizes.
Conclusion:
Collateral circulation is a critical determinant of prognosis in cerebral infarction. Enhancing collateral circulation may serve as a promising therapeutic strategy to improve clinical outcomes in affected patients.
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